Nanomedicine is the medical application of nanotechnology that uses various nanomaterials engineered to enhance targeted delivery of therapeutic and diagnostic agents for advanced treatment of many fatal diseases including cancer. Nanomedicine is typically designed to deliver water-insoluble drugs or nucleic acids in circulation with enhanced stability and to serve as contrast agents for multiple imaging modalities while targeting specific sites for drug delivery. The ultimate goal of nanomedicine is to achieve robust targeted delivery of complex assemblies that contain sufficient amount of multiple therapeutic and diagnostic agents for highly localized drug release with no adverse side effects and reliable detection of site-specific therapeutic response.
Engineering microfluidic modules with controlled 3D flow patterns that allow efficiently directed assemblies of multicomponent, multifunctional theranostic nanoparticles: lipid-PLGA nanoparticles (LPNPs), engineered high-density lipoprotein-mimetic nanoparticles (eHNPs), engineered low-density lipoprotein-mimetic nanoparticles (eLNPs), and their combinations. Optimizing 3D flow patterns in the microfluidic modules for maximal production of multicomponent nanoparticles while maintaining the accomplished nanoparticle qualities including the yield and homogeneity.
Ahn SI*, Park HJ*, Yom J, Kim T, and Kim Y, High-density lipoprotein-mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases (2018) Nano Research 11 (10): 5130-5143 (Link).
Ahn J, Ko J, Lee S, Yu J, Kim Y, and Jeon NL, Microfluidics in Nanoparticle Drug Delivery; From Synthesis to Pre-clinical Screening (2018) Advanced Drug Delivery Review 128: 29-53 (Link).
Sei YJ, Ahn J, Kim T, Shin EJ, Santiago-Lopez AJ, Jang SS, Jeon NL, Jang Y, and Kim Y, Detecting the functional complexities between high-density lipoprotein mimetics (2018) Biomaterials 170: 58-69 (Link). Selected as Leading Opinion.
Ahn J, Sei YJ, Jeon NL*, and Kim Y*, Probing the effect of bioinspired nanomaterials on angiogenic sprouting using a microengineered vascular system (2018) IEEE Transactions of Nanotechnology 17 (3): 393-397 (Link).
Toth MJ, Kim T, and Kim Y, Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices (2017) Lab on a Chip 17: 2805-2813 (Link).
Lee Chung B*, Toth MJ*, Kamaly N, Sei YJ, Becraft J, Mulder W, Fayad Z, Farokhzad OC, Kim Y*, and Langer R*, Nanomedicines for endothelial disorders (2015) Nano Today 10 (6): 759-776 (Link).
Kim Y* and Langer R*, Microfluidics in nanomedicine (2015) Reviews in Cell Biology and Molecular Medicine 1:127–152 (Link). Invited Book Chapter.
Kim Y*, Lobatto ME*, Kawahara T, Lee Chung B, Mieszawska AJ, Sanchez-Gaytan BL, Fay F, Senders M, Calcagno C, Becraft J, Saung MT, Gordon RE, Ma M, Farokhzad OC, Fayad ZA, Mulder WJM, and Langer R, Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis (2014) Proceedings of the National Academy of Sciences (PNAS) 111 (3): 1078-1083 (Link).
Kim Y*, Fay F*, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy E, Ma M, Moore KJ, Farokhzad OC, Fisher EA, Mulder WJM, Langer R, and Fayad ZA, Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics (2013) ACS Nano 7 (11): 9975-9983 (Link).
Mieszawska A, Kim Y, Gianella A, van Rooy I, Priem B, Labarre MP, Ozcan C, Cormode DP, Petrov A, Langer R, Farokhzad OC, Fayad ZA, and Mulder WJM, Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy (2013) Bioconjugate Chemistry 24 (9): 1429-1434 (Link).
Kim Y, Lee Chung B, Ma M, Mulder WJM, Fayad ZA, Farokhzad OC, and Langer R, Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices (2012) Nano Letters 12 (7): 3587–3591 (Link).