Advanced treatment of diseases such as cancer and atherosclerosis needs controlled delivery of multifunctional nanocarriers that contain multiple drugs that can target tumors with anti-angiogenic and cytostatic agents and a diversity of imaging agents that monitor the transport in the body. Optimized integration of manufacturing nanomaterials will contribute to advanced health technology not only because of rapid clinical translation of drugs but also due to reduction of any release of harmful byproducts.
We design and fabricate diverse microfluidic modules for diverse syntheses of multifunctional nanomaterials and integrates the modules to establish large-scale implementation of manufacturing processes scaled to economically and industrially relevant production level. The integrative system will facilitate good manufacturing practice (GMP) production and clinical translation in pharmaceutical and biomedical industry and enable reproducible and controlled synthesis of nanoparticles at scales suitable for rapid clinical development and commercialization.
Integrating engineered microfluidic modules for large-scale production of multifunctional and multicomponent nanomedicines
- Arduino-based high-precision microfluidic pressure control
- Multi-input/Multi-output (MIMO) control systems engineering
- Scalable manufacturing of multicomponent nanomaterials.
Toth MJ, Kim T, and Kim Y, Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices (2017) Lab on a Chip 17: 2805-2813 (Link).