While a variety of materials have been used to formulate nanomedicines for drug delivery and imaging applications, most of all, natural nanoparticles, thanks to their endogenous character and reliable stability in circulation, are well suited as a vehicle for targeted delivery of therapeutic or diagnostic agents. In particular, HDL, a natural nanoparticle, exhibits atheroprotective properties, such as the ability to remove and transport cholesterol from atherosclerotic plaques, to restore endothelial function and to reduce a risk of coronary artery disease.
We develop a cutting-edge microfluidic technology for the large-scale, continuous, and single-step synthesis of biologically active HDL-based nanomaterials. The microfluidic approach enables us to tailor the compositions of lipid, protein, and other therapeutic or diagnostic agents, such as simvastatin, a fluorophore, or inorganic nanocrystal cores such as gold, iron oxide, and quantum dot.
Our current projects include:
- targeted CNS drug delivery for the treatment of medulloblastoma in collaboration with Dr. Tobey MacDonald at Emory
- advanced CNS drug delivery in experimental Alzheimer’s disease in collaboration with Dr. Allan Levey and Dr. Srikant Rangaraju at Emory School of Medicine
- engineering of anti-miRNA transporting HDL for treating endothelial inflammation in experimental atherosclerosis in collaboration with Dr. Hak-Joon Sung at Yonsei University and Dr. Hanjoong Jo at Emory
Ahn SI*, Park HJ*, Yom J, Kim T, and Kim Y, High-density lipoprotein-mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases (2018) Nano Research 11 (10): 5130-5143 (Link).
Sei YJ, Ahn J, Kim T, Shin EJ, Santiago-Lopez AJ, Jang SS, Jeon NL, Jang Y, and Kim Y, Detecting the functional complexities between high-density lipoprotein mimetics (2018) Biomaterials 170: 58-69 (Link). Selected as Leading Opinion.
Ahn J, Sei YJ, Jeon NL*, and Kim Y*, Probing the effect of bioinspired nanomaterials on angiogenic sprouting using a microengineered vascular system (2018) IEEE Transactions of Nanotechnology 17 (3): 393-397 (Link).
Kim Y*, Fay F*, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy E, Ma M, Moore KJ, Farokhzad OC, Fisher EA, Mulder WJM, Langer R, and Fayad ZA, Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics (2013) ACS Nano 7 (11): 9975-9983 (Link).